The Ordered Extension of Pseudopodia by Amoeboid Cells in the Absence of External Cues

By using this site, you agree to the Terms of Use and Privacy Policy. Amoeboid cells demonstrating this pseudopod-driven motility can offer insights into many biological processes.

Properties of maintained split an de novo pseudopodia 0. We observed that a split pseudopod or a new de novo pseudopod have the same probability to become the parental pseudopod for subsequent pseudopod splitting data not shown. Reticulosida Aconchulinida Vampyrellidae Pseudosporida. In addition to actin polymerization, microtubules may also play an important role in cell migration where the formation of lamellipodia is involved.

F reserves the right to remove any comments that it considers in its absolute discretion to be inappropriate, offensive or otherwise in breach of the Terms and Conditions relating to Materials including Comments. Amoeboid motility is a complex and multiscale process, which involves bio-molecular reactions, cell deformation, and cytoplasmic and extracellular fluid motion. The results show that pseudopod extension in the absence of external cues is not random but highly co-coordinated, which may form the basis for internal and external cues to direct cell movement.

Sources and alternative views: As early as , however, it was shown that in the absence of external cues, cells exhibit a so-called correlated random walk [3] , an observation that has been reproduced for nearly all moving cells [4] — [7]. Story Source: CrossRef Google Scholar.

Unicellular Monadoid Amoeboid Coccoid Colonial s. Depending on the activity of PLA2 and guanylyl cyclase, this pseudopod is formed by splitting of an existing pseudopod or formed de novo on the cell body.

FEBS Lett. The results clearly support our proposal: Therefore, we have developed a pseudopod tracking tool that identifies the position and time of the start and end of pseudopod growth [12].

Dinokaryon Dinocyst Theca. A, 2nd ed.

Consequence of de novo and split pseudopodia for cell movement The aim of this study was to unravel how cells extend pseudopodia, and from there to understand how cells move in longer trajectories. Panel E shows the dispersal during time interval t; the symbols indicate the measured data, and the curves are the fit of the data to the equation of persistent movement see text. Unless the emerging pseudopod is mechanically locked intracellular, these asymmetric counterforces will correct the direction of the extending protrusion till the direction is perpendicular to the membrane.

The pioneering work of Potel and Mackay on cell trajectories of Dictyostelium movement revealed details on velocity and persistence time 4. Two subsequent pseudopodia can be split-split, split-novo, novo-split and the rare novo-novo. Cite chapter How to cite? Split and de novo pseudopodia have approximately the same length distribution, with an average of 5.

A novel cGMP signalling pathway mediating myosin phosphorylation and chemotaxis in Dictyostelium. We have chosen for an opposite strategy on the assumption that the extension of a pseudopod is the basic element for cell movement, and that shape changes and cell trajectories are the consequence of the pattern of pseudopod extension. Genes Dev.

Phytomyxea Cruciform division.

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In the present study we have explored pseudopod extension in the absence of external cues. Quantitative analysis of changes in cell shape of Amoeba proteus during locomotion and upon responses to salt stimuli.

Phycoplast Phragmoplast Flagellar apparatus. Back to tab navigation Fetching data from CrossRef.